The One can be layered in the morning underneath your moisturizer. It'll give your skin that plump, dewy glow on the surface while nourishing and balancing deep within. (If you're using a hyaluronic serum, try this in it's place instead!) At night after washing and drying your face, layer on The One Serum BEFORE your Perfect Change Serum. It will help lock in deep hydration, allowing you to reap all those benefits of Retinol +TCA without the pesky dry skin that can sometimes occur.

The One Serum can be used morning and night, but we always save our most active resurfacing products, like Perfect Change Serum for night time. So this combination of The One and perfect Change Serum would be incorporated into your evening lineup. 

In general the rule is layer products thinnest to thickest, but there is more behind why The One Serum gets layered first:

The molecular size of naturally occurring hyaluronic acid in The One is very small, which means this products easily penetrates the skin. This helps lock in deep hydration before using retinol, which will make your usage of this skin-changing product more comfortable during the adjustment phase (you've heard of retinol uglies right?!). The One Serum seriously compliments the results of retinol by ensuring the skin revealed is plump, dewy and hydrated.

Consistency and patience is key with medical-grade actives. i always recommend at lest a 12 week trial period when introducing any new products to your skin, give yourself time the results are worth it, I promise.