Congrats! You’ve taken a big step in improving your skin. We are excited for you! It is very important that you closely follow these instructions unless otherwise discussed with your provider.

**Booking this appointment does not ensure that you will receive Cosmelan MD on the day of your appointment (unless it has been pre-arranged with your provider.)

Once you are deemed a candidate for this treatment, you will receive the Cosmelan MD kit for either in-office application or to be done at home. Cosmelan MD involves a ‘leave on mask’ that is a thin peanut butter consistency. It is easily applied and worn for 5-10 hours depending on your skin type and instructions from your provider. Peeling and sensitivity may occur for the first few weeks. You will be required to follow a strict at-home protocol for a total of 90 days. Cosmelan MD is safe for ALL skin types and will ultimately help to eliminate melanin patches on the face for a more refined skin texture and tone.

Pre-Care for Cosmelan MD Peel:

  • Cosmelan MD should not be started within 2 weeks of a COVID vaccine
  • Avoid any chemical peel, laser, microneedling, or other skin procedures for 4 weeks prior to treatment with Cosmelan.
  • Refrain from waxing for 7 days prior to the treatment.
  • You should not use any hydroquinone containing products for at least 8-12 weeks before and after the Cosmelan MD Peel protocol.
  • Refrain from tanning beds and heavy sun exposure 2 weeks prior to your treatment.
  • Discontinue any glycolic acid or retinol containing products at least 5 days prior to treatment.
  • Do not start Cosmelan MD within 5 days of Botox or at least two weeks from receiving dermal filler.
  • Cosmelan MD may not be recommended for Rosacea skin types.
  • Cosmelan MD is not recommended for pregnant or nursing women.
  • If you have a history of cold sores or shingles, please tell your provider prior to treatment.


Home Care Protocol for Cosmelan MD Peel:

Day 1:

  • Your Cosmelan MD Peel, Cosmelan 1 cream, was applied at ______ am/pm.
  • Use a spray bottle with water to keep the mask moist if it begins to flake or feel dry.
  • Your provider told you how many hours to leave your mask on. Please remove your peel at that time. Set an alarm reminder for yourself.
  • Use lots of cold water to remove the mask. Towel off and apply the Melan Recovery Cream. You may feel some warmth/stinging/itchy sensations following the removal of the peel. Cool air/fan will help to ease this discomfort. Use of Aquaphor during the first week or two is ok to help relieve these symptoms throughout the day.

Day 2:

  • Use a gentle cleanser to wash skin and then towel dry.
  • Apply Melan Recovery Cream am/pm and Aquaphor as needed.
  • Use Melan 130+ Mesoprotech SPF during the day.

Day 3-30:

  • Use a gentle cleanser to wash skin and then towel dry.
  • Start Cosmelan 2 cream, only a pea-size amount, three times a day. Massage into the skin. Do not remove. Wash face before each application.
  • Apply Melan Recovery Cream 10-15 minutes after Cosmelan 2.
  • Use Melan 130+ Mesoprotech SPF during the day.

Month 2:

  • Use a gentle cleanser to wash skin and then towel dry.
  • Apply Cosmelan 2 only twice a day, morning and evening.
  • Apply Melan Recovery Cream 10-15 minutes after Cosmelan 2.
  • Use Melan 130+ Mesoprotech SPF during the day.

Month 3:

  • Use a gentle cleanser to wash skin and then towel dry.
  • Use Melan Recovery Cream in the morning followed by Melan 130+ Mesoprotech SPF during the day.
  • Apply Cosmelan 2 in the evening only after cleansing and follow with Melan Recovery Cream 10-15 minutes later.


  • The use of Cosmelan 2 cream can be adjusted for your comfort; if your skin is feeling sensitive, decrease use of Cosmelan 2 cream until you can tolerate it. Some discomfort is expected in the beginning but we never want you to be in pain.
  • Do NOT use any other active ingredients or products that include acids, retinols, or hydroquinone on your skin during your 3-month treatment with Cosmelan.
  • Do NOT do any sweaty exercise or swimming for at least 72 hours.
  • Do NOT use a hot tub, sauna or steam for 30 days following treatment.
  • Do NOT get another skin treatment or procedure on the treated area for at least 30 days following the protocol. No other skin treatments should be performed while you are following the home care protocol.
  • Do NOT use makeup for 3-5 days if possible. Light mineral makeup is ok, such as our Perfect Powder.
  • Do NOT have botox or any dermal filler performed for at least 5 days after the initial Cosmelan mask application.
  • To optimize your results, avoid sun exposure as much as possible and use SPF everyday.
  • During maintenance on Cosmelan 2, discontinue its use for 3-5 days prior to waxing and do not start until 3 days after waxing. No waxing should be performed in the first 4-6 weeks of the protocol.

**A ‘touch-up’ mask is typically recommended on or around Day 21 with the ¼ remaining Cosmelan 1 cream to address any stubborn areas of hyperpigmentation that remain. Please touch base with your provider prior to Day 21 via email and send along a set of makeup free progress pictures for assessment (front facing and each side profile).

Please do not hesitate to call or email the office if you have any questions about your Cosmelan MD peel. 858-230-2876

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